Optimal Timing for Cancer Screening and Adaptive Surveillance Using Mathematical Modeling

Optimal timing of computed tomography for assessing lymph nodes after neoadjuvant chemoradiotherapy for rectal cancer

Background: This study assessed the optimal timing of computed tomography for detection of metastatic disease in locoregional lymph nodes in patients with rectal cancer who have undergone chemoradiotherapy. Materials and Methods: This observational retrospective study was performed in a single institution. All patients with locally advanced rectal cancer treated with chemoradiotherapy, followed...

Mathematical Modeling and Lyapunov-Based Drug Administration in Cancer Chemotherapy

In this paper a new mathematical model is developed for the dynamics between tumor cells, normal cells, immune cells, chemotherapy drug concentration and drug toxicity. Then, the theorem of Lyapunov stability is applied to design treatment strategies for drug protocols that ensure a desired rate of tumor cell kill and push the system to the area with smaller tumor cells. Using of this theorem a...

Screening and surveillance for hereditary pancreatic cancer.

Hereditary factors are estimated to be involved in approximately 10% of patients with pancreatic carcinoma. Family members of patients with pancreatic cancer often worry about their own risk, especially after seeing the impact of the disease on the quality of life of their, usually deceased, relative. Some families with an increased risk of pancreatic cancer have genetic syndromes with known ge...

Screening and surveillance for colorectal cancer.

Pathologic reviews and clinical studies demonstrate that groups with increased cancer risk can be identified. It is estimated that about 3.5 per cent of colorectal cancers in this country are the result of known heritable cancer syndromes, such as familial polyposis. Much effort is currently being devoted to evaluation of biologic markers, such as cell surface antigens and their antibodies, orn...

Guidelines for colorectal cancer screening and surveillance.